You are studying an individual with very low levels of insulin in her blood. Further analysis indicates that cells of her pancreas are producing normal levels of this protein, but it is accumulating in the cytoplasm rather than being secreted from the cells. Which hypothesis makes the most sense to explain this observation?
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Answered on
Cells of her pancreas are producing normal levels of this protein, but it is accumulating in the cytoplasm rather than being secreted from the cells this is due to deletion of a single nucleotide sequence at the amino acid terminal side .
The deletion of a single nucleotide that code a small sequence of a gene results, affect the release of insulin outside the cells because the single sequence is responsible for carrying the insulin outside the cells . The cells of pancreas are producing the insulin normally but due to mutation in the singal sequence , due to which it can't excrete out of the cells and accumulate into the cytoplasm.