why does the charge on a protein vary with change in PH
Biology · High School · Thu Jan 21 2021
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Explanation: The pH has an influence on the redox potential of a metalloprotein because free protons or hydroxide ions alter the protonations state of the protein. Free protons can add to basic nitrogen sites, increasing the positive charge on the protein (or lowering negative charge).
Electrostatic interactions play a fundamental role in the structure and function of proteins. Due to ionizable amino acid residues present on the solvent-exposed surfaces of proteins, the protein charge is not constant but varies with the changes in the environment—most notably, the pH of the surrounding solution.