If negative selection of T-lymphoctyes in the thymus never occurred, what would likely happen? The specificity of the immune system would improve. T-lymphocytes would bind self-antigens. Mature T-lymphocytes would lack CD proteins. T-lymphocytes would be unable to bind nonself-antigens.
Biology · High School · Mon Jan 18 2021
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If negative selection of T-lymphocytes in the thymus never occurred, it would likely result in: B) T-lymphocytes would bind self-antigens.
- Negative selection in the thymus is a crucial process in the maturation of T-lymphocytes, wherein T-cells that recognize self-antigens (i.e., antigens from the body's own tissues) with high affinity are eliminated or rendered inactive. This process helps prevent mature T-cells from recognizing and attacking the body's own cells, thus reducing the likelihood of autoimmune reactions. If negative selection didn't occur, T-lymphocytes might not be properly trained to distinguish self-antigens from non-self antigens, leading to the possibility of binding self-antigens and causing autoimmunity.