Which of the following contributed to John Calhoun's resignation of the vice presidency in 1832?

John Calhoun resigned from the vice presidency in 1832 due to a disagreement with President Andrew Jackson over the issue of nullification and states' rights.

The specific event that led to Calhoun's resignation was the Nullification Crisis, which was triggered by the Tariff of 1828 (also known as the Tariff of Abominations) and the subsequent Tariff of 1832. Calhoun, who had previously supported protective tariffs, began to argue that a state had the right to nullify federal laws within its borders if it deemed those laws unconstitutional.

Calhoun, as a representative of South Carolina, supported the concept of nullification as a means to resist what he saw as oppressive federal tariffs. However, President Jackson was a staunch supporter of the Union and opposed the idea of nullification.

The Nullification Crisis escalated, and Calhoun found himself at odds with the administration. In 1832, Congress passed a compromise tariff known as the Tariff of 1833, but South Carolina continued to assert its right to nullify federal laws. Calhoun, feeling that he could better advocate for his state's position outside of the administration, resigned as vice president in December 1832.