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Domperidone is most often prescribed to women who have true, chronic low milk supply. This can be due to hormonal issues, insufficient glandular tissue, or wide breast spacing, among other reasons.
The World Health Organization (WHO) and the U.S. Food and Drug Administration (FDA) warn against the use of domperidone, citing safety concerns about an intravenous form of domperidone that was reportedly linked to cardiac arrhythmias and cardiac arrests. This form of domperidone has been withdrawn from the market.