Place the following events in the proper order. 1) Activation of one or more cellular signaling proteins. 2) Dissociation of Ga from the G protein complex. 3) Production of a second messenger, like cAMP. 4) Replacement of GDP by GTP on the Ga after interaction with an activated GPCR. 5) Conformational change in the Ga subunit causing a decreased affinity for the Gb g subunit. 6) Ga-subunit with its attached GTP activates an effector like adenylyl cyclase.
Biology · High School · Sun Jan 24 2021
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The events you've listed pertain to a G protein-coupled receptor (GPCR) signaling pathway. Here is the proper order in which they occur:
1) Replacement of GDP by GTP on the Ga after interaction with an activated GPCR.
2) Conformational change in the Ga subunit causing a decreased affinity for the Gb g subunit.
3) Dissociation of Ga from the G protein complex.
4) Ga-subunit with its attached GTP activates an effector like adenylyl cyclase.
5) Activation of one or more cellular signaling proteins.
6) Production of a second messenger, like cAMP.