Which of the following drugs is associated with the reaction
of Stevens-Johnson syndrome? (Safdarjung NO 2018)
a. Valproic acid b. Quinidine
c. Isoniazid d. Procainamide
Medicine ยท Wed Jul 13 2022
Answered on
Answer A is correct - Valproic acid
Stevens-Johnson syndrome (SJS) is one of the most severe adverse drug reactions occurring in pediatric population. It is a type III reaction .
Many drugs including antibiotics, NSAIDs, and anticonvulsants can cause SJS. anticonvulsants (e.g., Valproic acid) are the commonest group of drugs causing Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).