Find the mRNA and amino acid sequence for sickle cell hemoglobin DNA: CACGTGGACTGAGGACACCTC. Sickle cell hemoglobin mRNA: Sickle cell hemoglobin amino acid sequence:

Biology · Middle School · Mon Jan 18 2021

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To determine the mRNA sequence and subsequently the amino acid sequence for sickle cell hemoglobin (HbS) from the given DNA sequence, we'll transcribe the DNA sequence into mRNA using the complementary base pairing rules:

Given DNA sequence: CACGTGGACTGAGGACACCTC

mRNA is synthesized by replacing thymine (T) with uracil (U) and keeping the rest of the bases complementary:

DNA: C A C G T G G A C T G A G G A C A C C T C

mRNA: G U G C A C C U G A C U C C U G U G G A G

Now, we'll use the mRNA sequence to determine the amino acid sequence using the genetic code (codon table):

mRNA sequence: GUGCACCUGACUGACCCUGUG

The corresponding amino acids for each codon are:

GUU → Valine (Val)

GCA → Alanine (Ala)

CUG → Leucine (Leu)

ACU → Threonine (Thr)

GAC → Aspartic Acid (Asp)

CUG → Leucine (Leu)

ACU → Threonine (Thr)

CCC → Proline (Pro)

UGU → Cysteine (Cys)

Therefore, the amino acid sequence for the sickle cell hemoglobin mRNA sequence GUGCACCUGACUGACCCUGUG is: Val-Ala-Leu-Thr-Asp-Leu-Thr-Pro-Cys.

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