Based on this picture, how do you think a DNA molecule makes a copy of itself? (Hint: Look at the bottom two “rungs” of the ladder.) This a gizmo Plz help

Biology · Middle School · Thu Feb 04 2021

Answered on

Without seeing the actual picture, I will describe the general process by which a DNA molecule makes a copy of itself, which is known as DNA replication. The process is somewhat similar to opening a zipper, which might be what your picture with the "ladder" is depicting—as the two strands unzip to create two single strands, each of which serves as a template for the new strands.

1. Unwinding of the Double Helix: The DNA molecule first unwinds, separating the two strands of the double helix. Special enzymes called helicases are responsible for this action.

2. Breaking Hydrogen Bonds: As the helicase unwinds the DNA, the hydrogen bonds between the base pairs (the "rungs" of the ladder) are broken.

3. Priming: Another enzyme called primase synthesizes a short RNA primer, which provides a starting point for DNA synthesis.

4. Synthesis of New Strand: DNA polymerase enzymes add new complementary nucleotides to the exposed bases on each single strand. Adenine pairs with thymine (A-T), and guanine pairs with cytosine (G-C). This step may be what is hinted at in the gizmo's picture, by showing the base pairing along the "rungs" of the ladder.

5. Leading and Lagging Strands: One new strand, called the leading strand, is made continuously, while the other new strand, called the lagging strand, is made in short segments called Okazaki fragments.

6. Joining the Segments: On the lagging strand, the Okazaki fragments are joined together by an enzyme called DNA ligase to form a continuous strand.

7. Termination: Once all bases are paired and the DNA strands are complete, the replication machinery disassembles, and the DNA molecule rewinds into the double helix structure.